The Science of How the Body Heals Itself with William Li, M.D.

Sentara Health
21 Dec 201873:05
EducationalLearning
32 Likes 10 Comments

TLDRDr. William Li, a renowned physician, molecular biologist, and author, discusses the profound impact of diet on disease prevention and treatment. He emphasizes that our bodies have evolved defense systems, such as angiogenesis, stem cells, microbiome, DNA protection, and the immune system, which can be supported by certain foods. Li highlights the role of natural chemicals in foods, like genistein in soy and lycopene in tomatoes, which have anti-angiogenic properties that can help prevent diseases like cancer. He also addresses the importance of understanding how our bodies respond to food and the potential of using food as medicine. Li's talk is an insightful exploration of the intersection between nutrition, health, and the body's innate healing capabilities.

Takeaways
  • 👨‍⚕️ Dr. William Li is a leading expert in angiogenesis and has contributed to the development of novel treatments for various diseases, including cancer, cardiovascular disease, and diabetes.
  • 🌱 The concept of 'Eat to Beat Disease' emphasizes the role of diet in preventing and treating illnesses, shifting the focus from just the absence of food to the presence of defense systems in the body.
  • 🌿 Our bodies are hardwired with defense systems such as angiogenesis, stem cells, microbiome, DNA protection, and immune system, which are supported by certain foods and can be impaired by others.
  • 🥗 The natural chemicals in plants, originally evolved for the plants' defense, interact with human cells and can have positive health effects when consumed as part of our diet.
  • 🔬 Scientific research, including epidemiological studies, shows associations between the consumption of certain foods and decreased risks of diseases like cancer and diabetes.
  • 🍅 Lycopene in tomatoes, when prepared in certain ways (cooked with heat and oil), has been linked to a reduced risk of prostate cancer.
  • 🚫 Processed foods and artificial sweeteners can have negative impacts on our gut bacteria, which in turn affects our overall health and is linked to various diseases.
  • 🍫 Foods like dark chocolate can stimulate stem cells, which play a crucial role in regeneration and repair within the body.
  • 🥦 Foods rich in bioactives, such as broccoli sprouts, can boost the immune system, highlighting the connection between diet and immune response.
  • 🌟 'Grand slam' foods like turmeric affect multiple defense systems, providing a comprehensive approach to health and disease prevention.
  • 🌱 The importance of a plant-based, whole-food diet is emphasized for its potential to activate the body's natural defense systems and improve overall health.
Q & A
  • What is Dr. Lee's professional background and what is his focus in the medical field?

    -Dr. Lee is a world-renowned physician, molecular biologist, and leading author. He is the medical director of the Angiogenesis Foundation, and his work has led to the effective prevention, novel treatment, and even reversal of various diseases including cancer, cardiovascular disease, chronic wheeze, obesity, diabetes, and retinal diseases.

  • How many times has Dr. Lee's TED talk 'Can we eat to starve cancer' been viewed?

    -Dr. Lee's TED talk 'Can we eat to starve cancer' has been viewed over 11 million times.

  • What is the significance of the discovery of the mesentery and the space between organs as new organs?

    -The recognition of the mesentery and the space between organs as new organs underscores how much we still have to learn about the human body. These discoveries add to our understanding of the body's structure and potentially how it communicates and functions, which could have implications for disease treatment and overall health.

  • What does Dr. Lee suggest is the key to understanding how to eat to beat disease?

    -Dr. Lee suggests that to truly understand how to eat to beat disease, it's not only about the food but also about how our bodies work and respond to the food. He emphasizes the importance of considering our body's defense systems and how they interact with the food we consume.

  • What is the 'Health Expedition' initiative that Dr. Lee leads?

    -The 'Health Expedition' is an initiative led by Dr. Lee in his organization. It aims to explore how we can normally stay healthy and why we don't get sick more often, looking at it from the perspective of maintaining health rather than just conquering disease.

  • How does Dr. Lee propose to reconcile the desire to find a 'magic answer' in food with the emerging signs about different foods?

    -Dr. Lee proposes that we should look beyond just listing favorite foods and instead examine the natural substances within those foods, such as fiber, vitamins, oils, and other bioactives. He suggests using epidemiological studies to understand the outcomes of eating these foods and to consider the doses associated with positive outcomes.

  • What is the significance of the Rosebud neuron discovered in humans?

    -The discovery of the Rosebud neuron in humans signifies that there is still much to learn about the human body and its functions. This new type of brain cell could potentially lead to new insights about brain function and neurological disorders.

  • How does Dr. Lee relate the concept of a fortress to the body's defense systems?

    -Dr. Lee uses the analogy of a fortress to describe the body's defense systems. Just as a fortress is designed with various defense mechanisms like a moat, a murder hole, and a spiral staircase, the body has multiple defense systems like angiogenesis, stem cells, microbiome, DNA protection, and the immune system that work together to protect against disease.

  • What is the role of angiogenesis in disease?

    -Angiogenesis is the growth of blood vessels, which is crucial for supplying oxygen and nutrients to the body's cells. When angiogenesis is compromised, it can lead to diseases such as cancer, cardiovascular disease, and others. On the other hand, the inappropriate growth of blood vessels can also contribute to disease, particularly in the growth and spread of tumors.

  • How does Dr. Lee suggest using food as medicine?

    -Dr. Lee suggests that we can use the tools of medicine to study food and its natural chemicals, comparing their effects to those of pharmaceuticals. He provides examples of foods and their bioactive components that have anti-angiogenic properties, which can help in preventing and treating diseases like cancer.

  • What are some examples of foods that have been shown to have anti-angiogenic properties?

    -Some examples of foods with anti-angiogenic properties mentioned by Dr. Lee include soy (specifically genistein), tomatoes (rich in lycopene), and certain varieties of olive oil. These foods contain natural chemicals that can inhibit the growth of new blood vessels, a process that is often hijacked by cancer cells to grow and spread.

Outlines
00:00
🎓 Dr. Lee's Introduction and the Impact of Diet on Disease

Dr. Lee, a distinguished physician and molecular biologist, is recognized for his work in preventing and reversing various diseases through angiogenesis. His TED talk and upcoming book emphasize the significance of diet in combating diseases. He appreciates the event organizers and acknowledges the importance of making informed dietary choices for disease prevention. He also introduces the concept of understanding how our bodies respond to food for effective disease management.

05:01
🌐 The Global Impact of Disease and the Role of Diet

The World Health Organization and United Nations recognize the universality of non-communicable diseases like cardiovascular disease, cancer, and diabetes. Dr. Lee discusses the environmental causes of cancer, the role of diet in disease, and the potential of using dietary changes to focus on the positive aspects of food. He emphasizes the power of scientific knowledge in understanding the body's complex relationship with food.

10:02
🧬 The Body's Defense Systems and How Diet Can Support Them

Dr. Lee presents the body as a fortress with defense systems, including angiogenesis, stem cells, microbiome, DNA protection, and the immune system. These systems work together to protect against various diseases. He explains how certain foods have evolved to contain bioactive chemicals that can interact with our body's cells, potentially enhancing these defense systems.

15:03
🚫 The Consequences of Imbalanced Angiogenesis

Dr. Lee discusses angiogenesis, the growth of new blood vessels, which is a critical process for healing and regeneration but can also contribute to diseases like cancer when misregulated. He explains how the body maintains a balance of blood vessels and how certain foods can influence this process, either by promoting or inhibiting angiogenesis.

20:04
🥗 Food as a Tool for Health and Disease Management

Dr. Lee explores the concept of food as medicine, emphasizing that certain bioactive compounds in food can have anti-angiogenic effects, potentially helping to prevent diseases like cancer. He cites studies on soy and tomatoes, explaining how these foods can have a positive impact on health when consumed in the right way.

25:05
🌱 The Role of Food in Stimulating Angiogenesis

Dr. Lee delves into the emerging field of angiogenesis-stimulating foods, which can prompt the growth of new blood vessels where they are needed. He provides examples such as barley and fruit peels, which contain natural chemicals that can enhance blood vessel growth and overall circulation.

30:07
🌿 The Power of Regeneration and Stem Cells in Health

Dr. Lee discusses the regenerative capabilities of stem cells within the human body and how they play a role in healing from injuries. He highlights how certain foods and dietary patterns can stimulate stem cells, while others can impair them, and the potential of using food to support stem cell function and health.

35:07
🍫 Foods That Target Cancer Stem Cells and Support the Microbiome

Dr. Lee reveals that specific foods can target cancer stem cells, potentially preventing the recurrence of cancers. He also discusses the importance of the microbiome in health and how foods like kimchi, sauerkraut, and sourdough bread can contribute beneficial bacteria to our gut.

40:07
🧠 The Influence of the Microbiome on Behavior and Psychology

Dr. Lee explains the complex interactions between the microbiome and the brain, including how certain bacteria can affect behavior and mental health. He also touches on the impact of food on the microbiome and how it can influence various aspects of our health, including weight management and the immune system.

45:09
🧬 How Food Can Modify Our DNA and Enhance Our Immune System

Dr. Lee discusses how certain foods can epigenetically modify our DNA, turning on good genes and turning off bad ones, potentially reducing the risk of diseases like cancer. He also highlights the immune-boosting properties of some foods and the importance of maintaining a strong immune system through diet.

50:11
🏥 The Need for Healthier Hospital Food and Cultural Changes

Dr. Lee addresses the issue of unhealthy food being served in hospitals and the need for change. He shares examples of progressive changes in some hospitals and the importance of advocating for healthier options. He also emphasizes the role of education and collective effort in bringing about this change.

Mindmap
Keywords
💡Angiogenesis
Angiogenesis refers to the process through which the body forms new blood vessels. It is a natural part of growth, healing, and tissue repair. In the context of the video, Dr. Lee discusses how an imbalance in angiogenesis can lead to diseases such as cancer, where new blood vessels supply tumors with nutrients, allowing them to grow. The video also explores the potential of using diet to influence angiogenesis as a preventative or therapeutic approach.
💡Stem Cells
Stem cells are undifferentiated cells that have the potential to develop into many different cell types. They play a crucial role in tissue regeneration and repair. In the video, Dr. Lee explains that as we age, our stem cells can become less effective, contributing to various diseases and conditions. He also discusses how certain foods can stimulate stem cell activity, which is integral to the body's defense and healing mechanisms.
💡Microbiome
The human microbiome consists of the trillions of microorganisms, including bacteria, that live in and on our bodies. These microbes play a significant role in health and disease. Dr. Lee talks about how an imbalance in the gut microbiome (dysbiosis) is linked to a range of health issues, and how certain foods can positively influence the microbiome to support health.
💡DNA Protection
DNA protection involves the body's mechanisms to prevent damage to the genetic material within our cells. The video highlights that certain foods can enhance these protective mechanisms, thereby reducing the risk of diseases like cancer that often involve DNA mutations. Dr. Lee emphasizes the role of diet in supporting our body's natural defense systems against DNA damage.
💡Immune System
The immune system is a complex network of cells, tissues, and organs that work together to defend the body against invaders. In the video, Dr. Lee discusses how the immune system declines with age but can be supported through diet. He also mentions the potential of immunotherapy in cancer treatment and how dietary choices can influence its effectiveness.
💡Plant-Based Diet
A plant-based diet consists predominantly or entirely of foods derived from plants, including vegetables, grains, legumes, nuts, and fruits. Dr. Lee advocates for a plant-based diet, explaining that it can provide the necessary nutrients to support the body's defense systems. He also addresses misconceptions about certain plant foods, such as the presence of lectins in some plants, and emphasizes the importance of critical evaluation of nutritional information.
💡Lectins
Lectins are proteins found in many plants, which some believe can be harmful when consumed. In the video, Dr. Lee addresses concerns about lectins, particularly in the context of plant-based diets. He encourages viewers to critically evaluate the scientific evidence regarding lectins and their impact on health, rather than relying solely on media reports that may be misleading.
💡Cancer Stem Cells
Cancer stem cells are a subpopulation of cells within a tumor that have the ability to self-renew and generate the heterogeneous lineages of cancer cells that comprise the tumor. Dr. Lee discusses the importance of targeting cancer stem cells as a strategy to prevent tumor recurrence. He also mentions that certain foods have been shown to target these cells, potentially offering a dietary approach to complement traditional cancer treatments.
💡Anti-Angiogenic Therapy
Anti-angiogenic therapy is a type of treatment that aims to stop the growth of new blood vessels that supply tumors, thereby starving the cancer of nutrients and oxygen. In the video, Dr. Lee talks about his research into using food to achieve anti-angiogenic effects, which could be a natural and preventive approach to cancer treatment.
💡Genomic Screening
Genomic screening involves analyzing an individual's genome to identify mutations that may increase the risk of certain diseases, such as cancer. Dr. Lee mentions genomic screening as a tool for early cancer detection. However, he also points out that only a small percentage of cancers are detectable through genomic screening, emphasizing that environmental factors, including diet, play a significant role in the development of most cancers.
💡Precision Medicine
Precision medicine is an approach to patient care that allows doctors to select treatments that are most likely to help patients based on a genetic understanding of their disease. Dr. Lee discusses the move towards precision medicine, where treatments are tailored to the individual's genetic makeup. This approach is particularly relevant in understanding how different individuals may respond to certain foods or dietary patterns in terms of their health outcomes.
Highlights

Dr. Lee discusses the significant impact of diet on disease prevention and reversal, highlighting the role of angiogenesis, stem cells, microbiome, DNA protection, and immune system in health.

His TED talk, 'Can We Eat to Starve Cancer?' has been viewed over 11 million times, emphasizing the public interest in the link between nutrition and cancer.

Dr. Lee's new book, 'Eat to Beat Disease,' set to release in March 2019, promises to delve deeper into the science of using food to combat various diseases.

The concept of food as medicine is explored, with Dr. Lee presenting evidence that certain foods and their bioactive components can have similar effects to pharmaceutical drugs.

A shift from just identifying favorite foods to understanding the bioactive substances within them is highlighted as a key advancement in nutritional science.

Epidemiological studies are being used to correlate diet with health outcomes, providing insights into the effectiveness of certain foods in disease prevention.

Dr. Lee emphasizes the importance of precision medicine, tailoring dietary recommendations to an individual's genetic makeup and health status.

The idea that health is not just the absence of disease but the presence of functional defense systems is a paradigm shift proposed by Dr. Lee.

The body's ability to maintain a balance of blood vessels through angiogenesis is crucial for fighting diseases like cancer, cardiovascular disease, and diabetes.

Dr. Lee presents evidence that certain foods, such as soy and tomatoes, have anti-angiogenic properties that can help prevent diseases like cancer.

The impact of food preparation methods on the bioavailability of nutrients is discussed, with examples of how cooking can increase the benefits of tomatoes.

The role of the gut microbiome in overall health is underscored, with examples of how certain foods can positively influence bacterial balance.

Dr. Lee addresses the concern over lectins in plants by directing the audience to scientific resources for clarification, emphasizing the importance of evidence-based information.

The influence of diet on the effectiveness of modern medical treatments, such as immunotherapy for cancer, is a significant point raised by Dr. Lee.

The need for hospitals to provide healthier food options for patients is highlighted as a critical area for improvement in the healthcare system.

Dr. Lee calls for collective action to improve the nutritional content of meals served in institutions like hospitals and schools.

The potential of plant-based diets to provide all necessary nutrients and promote health is a key takeaway from Dr. Lee's talk.

Transcripts
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